The role of SDF_1α/CXCR4 axis in non-antibody mediated TRALI in cardiac surgery patients

Abstract

Background: Acute lung injury (ALI) after extracorporeal circulation can originate from multiple causes, including transfusion. Despite improvements in blood safety policy, transfusion-related lung injury (TRALI) continues to occur, suggesting an incomplete understanding of its pathogenesis. Objectives: To evaluate the association between the composition of the red blood cell unit (RBC) and the onset of ALI after transfusion, defined by a ratio between partial pressure of oxygen (PaO2) and the fraction of inspired oxygen (FiO2) ≤ 300 mmHg in the first 3 days postoperatively. Methods: Adults undergoing scheduled cardiac surgery at Nantes University Hospital between September 2016 and March 20..